Medical Community Resources

Scalp Cooling Clinical Studies

New Studies

JMRO 1 (2021) 1-13 DOI: 10.53011/JMRO.2021.01.01
The Breast, July 2020, 26(7), 1296-1301 https://doi.org/10.1111/tbj.13711
Curr. Oncol. 2022, 29(10), 7218-7228; https://doi.org/10.3390/curroncol29100569
Oncol Res Treat 2022;45:395–399 DOI: 10.1159/000523759
Br J Cancer 2019 Aug;121(4):325-331. doi: 10.1038/s41416-019-0520-8

Read more studies here: www.scalpcoolingstudies.com

Past Studies

Abramov 2011

Abramov M, Semenova I. Cooling of the scalp to prevent anticancer chemotherapy-induced alopecia. European Journal Cancer 2011;47:S321 (abstract #4245).

Lemieux 2015

Lemieux J, Provencher L, Perron L, Brisson J, Amireault C, Blanchette C, Maunsell E. No effect of scalp cooling on survival among women with breast cancer. Breast Cancer Research and Treatment 2015;149:263-268.

Adams 1992

Adams L, Lawson N, Maxtred KJ, Symonds RP. The prevention of hair loss from chemotherapy by the use of cold-air scalp-cooling. European Journal Cancer Care 1992;1(5):16-18.

Lofti-Jam 2008

Lofti-Jam K, Carey M, Jefford M, Schofield P, Charleson C, Aranda S. Nonpharmacologic strategies for managing common chemotherapy adverse effects: A systematic review. Journal Clinical Oncology 2008;26(34):5618-5629.

American Cancer Society 2015

American Cancer Society. Cold Caps (Scalp Hypothermia). 2015; Accessed on 16 November 2015 at: http://www.cancer.org/treatment/treatmentsandsideeffects/physicalsideeffects/chemotherapyeffects/cold-caps.

Lovejoy 1979

Lovejoy NC. Preventing hair loss during adriamycin therapy. Cancer Nursing 1979;2(2):117-121.

Betticher 2013

Betticher DC, Delmore G, Breitenstein U, Anchisi S, Zimmerli-Schwa B, Müller A, von Moos R, Hügli-Dayer AM, Schefer H, Bodenmann S, Bühler V, Trueb RR. Efficacy and tolerability of two scalp cooling systems for the prevention of alopecia associated with docetaxel treatment. Support Care Cancer 2013;21:2565-2573.

MacDuff 2003

Macduff C, Mackenzie T, Hutcheon A, Melville L, Archibald H. The effectiveness of scalp cooling in preventing alopecia for patients receiving epirubicin and docetaxel. European Journal Cancer Care 2003;12:154-161.

Breed 2011

Breed WPM, van den Hurk JG, Peerebooms. Presentation, impact and prevention of chemotherapy-induced hair loss. Expert Review of Dermatology 2011;6(1):109-125.

Massey 2004

Massey CS. A multicentre study to determine the efficacy and patient acceptability of the Paxman Scalp Cooler to prevent hair loss in patients receiving chemotherapy. European Journal Oncology Nursing 2004;8:121-130.

Choi 2014

Choi EK, Kim I-R, Chang O, Knag D, Nam S-J, Lee JE, Lee SK, Im Y-H, Park YH, Cho J. Impact of chemotherapy-induced alopecia distress on body image, psychosocial well-being, and depression in breast cancer patients. Psycho-Oncology 2014;23:1103-1110.

Maxwell 1980

Maxwell MB. Scalp tourniquets for chemotherapy-induced alopecia. Journal of Nursing 1980;80(5):900-903.

Christodoulou 2002

Christodoulou C, Klouvas G, Efstathiou E, Zervakis D, Papazachariou E, Plyta M, Skarlos DV. Effectiveness of MSC cold cap system in the prevention of chemotherapy-induced alopecia. Oncology 2002;62:97-102.

Moher 2009

Moher D, Liberati A, Tetzlaff J, Altman DG, The PRISMA Group. Preferred reporting items for systematic reviews and meta-analyses: The PRISMA statement. PLoS Med 2009;6(6):e10000097. doi:10.1371/journal.pmed10000097.

Dean 1983

Dean JC, Griffith KS, Cetas TC, Mackel CL, Jones SE, Salmon SE. Scalp hypothermia: A comparison of ice packs and the Kold Kap in the prevention of doxorubicin-induced alopecia. Journal Clinical Oncology 1983;1(1):33-37.

Mols 2009

Mols F, van den Hurk CJG, Vingerhoets AJJM. Scalp cooling to prevent chemotherapy-induced hair loss: practical and clinical consideration. Support Care Cancer 2009;17:181-9.

Dougherty 1996

Dougherty L. Scalp cooling to prevent hair loss in chemotherapy. Cancer Nursing 1996;11:507-509.

NCT01831024 2015

Rugo HS, Klein P, Melin SA, Hurvitz SA, Melisko ME, Moore A, Park GD, Bågeman E, D’Agostino RB, Ver Hoeve ES, Esserman L, Cigler T. Prevention of chemotherapy-induced alopecia with scalp cooling. NCT01831024Accessed on November 27, 2015 at: https://clinicaltrials.gov/ct2/show/NCT01831024.

Dougherty 2006

Dougherty L. Comparing methods to prevent chemotherapy-induced alopecia. Cancer Nursing Practice 2006;5(6):25-31.

NCT01986140 2015

Assessed on November 29, 2015 at: https://clinicaltrials.gov/ct2/show/NCT01986140?term=paxman&rank=1

Edelstyn 1977

Edelstyn GA, Salmon SE, Griffith KS. Prevention of doxorubicin-induced hair loss with scalp hypothermia. Lancet 1977;310(8031):253-254.

Parker 1987

Parker R. The effectiveness of scalp hypothermia in preventing cyclophosphamide-induced alopecia. Oncology Nursing Forum 1987;14(6):49-53.

Elkström 2005

Elkström B, Rosenberg P, Gustavsson A, Johansson B. Scalp cooling to prevent chemotherapy-induced hair loss. SBU- The Swedish Council on Technology Assessment in Health Care 2005;Access on 16 November 2015 at: www.sbu.se/upload/Publikationer/Content0/3/Scalp_Cooling_Prevent_ChemotherapyInduced_Hair_Loss_200506.pdf SBU – scalp cooling to prevent chemotherapy induced hair loss.

Poder 2011

Poder TG, He J, Lemieux R. Effectiveness of scalp cooling in chemotherapy. Bulletin du Cancer 2011;98(9):1119-1129.

Fried 1998

Fried G, Kuten A, Vizel B, Drumea K, Haim N. Scalp cooling system (Thairapy system) in the prevention of alopecia in adjuvant CMF chemotherapy for breast cancer. European Journal Cancer 1998;34:S42 (abstract # P109).

Protiere 2002

Portiere C, Evans K, Camerlo J, d’Ingrado M, Macquart-Moulin G, Viens P, Maraninchi D, Genre D. Efficacy and tolerance of a scalp-cooling system for prevention of hair loss and the experience of breast cancer patients treated with adjuvant chemotherapy. Support Care Cancer 2002;10:529-537.

Friedrichs 2014

Friedrichs K, Carstensen MH. Successful reduction of alopecia induced by anthracycline and taxane containing adjuvant chemotherapy in breast cancer – clinical evaluation of sensor-controlled scalp cooling. SpringerPlus 2014;3:500.

Ridderheim 2003

Ridderheim M, Bjurberg M, Gustavsson A. Scalp hypothermia to prevent chemotherapy-induced alopecia is effective and safe: a pilot study of a new digitized scalp-cooling system used in 74 patients. Support Care Cancer 2003;11:371-377.

Giaccone 1988

Giaccone G, Di Giulio F, Morandini MP, Calciati A. Scalp hypothermia in the prevention of doxorubicin-induced hair loss. Cancer Nursing 1988;11(3):170-173.

Ron 1997

Ron I, Kalmus Y, Kalmus Z, Inbar M, Chaitchik S. Scalp cooling in the prevention of alopecia in patients receiving depilating chemotherapy. Supportive Care in Medicine 1997;5:136-138.

Grevelman 2005

Grevelman EG, Breed WPM. Prevention of chemotherapy-induced hair loss by scalp cooling. Annals of Oncology 2005;16:352-358.

Shin 2014

Shin H, Jo SJ, Kim DH, Kwon O, Myung S-K. Efficacy of interventions for prevention of chemotherapy-induced alopecia: A systematic review and meta-analysis. International Journal of Cancer 2014;136:E442-E454.

Guy 1982

Guy R, Parker H, Shah S, Geddes D. Scalp cooling by thermocirculator. Lancet 1982;319(8278):937-938.

Song 2010

Song F, Parekh S, Hooper L, Loke YK, Ryder J, Sutton AJ, Kwok CS, Pang C, Harvey I. Dissemination and publication of research findings: an updated review of related biases. Health Technology Assessment 2010;14(8):1-193.

Hedges 1985

Hedges LV, Olkin I. Statistical methods for meta-analysis. 1st edition. New York. Academic Press 1985.

Spaeth 2008

Spaeth D, Luporsi E, Weber B. Efficacy and safety of cooling helmets (CH) for the prevention of chemotherapy-induced alopecia (CIA): a prospective study of 911 patients. Journal Clinical Oncology 2008;26(20 Suppl):9654.

Hesketh 2004

Hesketh PJ, Batchelor D, Golant M, Lyman GH, Rhodes N, Yardley D. Chemotherapy-induced alopecia: psychosocial impact and therapeutic approaches. Support Care Cancer 2004;12:543-549.

Tachi 2015

Tachi T, Teramanchi H, Tanaka K, Asano S, Osawa T, Kawashima A, Yasuda M, Mizui T, Nakada T, Noguchi Y, Tsuchiya T, Goto C. The impact of outpatient chemotherapy-related adverse events on the quality of life of breast cancer patients. PLOS One 2015;10(4):e0124169. doi:10.1371/journal.pone.0124169.

Higgins 2011

Higgins JPT, Green S. Cochrane Handbook for Systematic Reviews of Interventions. The Cochrane Collaboration 2011;Version 5.1.0 [updated March 2011]:Available from www.cochrane-handbook.org.

Tollenaar 1994

Tollenaar RA, Liefers GJ, Reelaer van Driel OJ, van de Velde CJ. Scalp cooling has no place in the prevention of alopecia in adjuvant chemotherapy for breast cancer. European Journal Cancer 1994;30A(10):1448-1453.

Hillen 1990

Hillen HF, Breed WP, Botman CJ. Scalp cooling by cold air for the prevention of chemotherapy-induced alopecia. Netherland Journal Medicine 1990;37:231-235.

van den Hurk 2013

van den Hurk CJG, van den Akker-van Marle ME, Breed WPM, van de Poll-Franse LV, Norteri JWR, Coebergh JWW. Impact of scalp cooling on chemotherapy-induced alopecia, wig use and hair growth of patients with cancer. European Journal of Oncology Nursing 2013;17(5):536-540.

Johansen 1985

Johansen LV. Scalp hypothermia in the prevention of chemotherapy-induced alopecia. Acta Oncologica 1985;24:113-116.

van den Hurk 2013(2)

van den Hurk CJG, Komen MMC, Norteri JWR, Goey SH, Breed WPM. Short post-infusion scalp cooling time still prevents docetaxel induced alopecia. European Journal Cancer 2013;49:S273.

Katsimbri 2000

Katsimbir P, Bamias A, Pavlidis N. Prevention of chemotherapy-induced alopecia using an effective scalp cooling system. European Journal Cancer 2000;36:766-771.

van den Hurk 2013(3)

van den Hurk CJG, van de Poll-Franse LV, Breed WPM, Coebergh JWW, Nortier JWR. Scalp cooling to prevent alopecia after chemotherapy can be considered safe in patients with breast cancer. The Breast 2013;22:1001-1004.

Kennedy 1982

Kennedy M, Packard R, Grant M, Padilla G, Presant C, Chillar R. The effects of using Chemocap® on occurrence of chemotherapy-induced alopecia. Oncology Nursing Forum 1982;10(1):19-24.

van den Hurk 2014

van den Hurk CJ, van den Akker-van Malre ME, Breed WP, van de Poll-Franse LV, Nortier JW, Coebergh JW. Cost-effectiveness analysis of scalp cooling to reduce chemotherapy-induced alopecia. Acta Oncologica 2014;53(1):80-87.

Komen 2011

Komen MMC, Smorenburg CH, Breed WPM, van den Hurk, CJG, Nortier JW. Optimal pre-infusion cooling time in patients treated with chemotherapy and scalp cooling. European Journal Cancer 2011;47:S320 (abstract #4242).

van den Hurk 2014(2)

van den Hurk CJG, van den Akker-van Marle ME, Breed WP, van de Poll-Franse LV, Nortier JW, Coebergh JW. Cost-effectiveness analysis of scalp cooling to reduce chemotherapy-induced alopecia. Acta Oncologica 2014;53:80-7.

Komen 2013

Komen MMC, Smoreenburg CH, van den Hurk CJG, Nortier JWR. Factors influencing the effectiveness of scalp cooling in the prevention of chemotherapy-induced alopecia. The Oncologist 2013;18:885-891.

Wheelock 1984

Wheelock JB, Myers MB, Krebs HB, Goplerud DR. Ineffectiveness of scalp hypothermia in the prevention of alopecia in patients treated with doxorubicin and cisplatin combinations. Cancer Treatment Reports 1984;68:1387-1388.

Lemieux 2008

Lemieux J, Maunsell E, Provencher L. Chemotherapy-induced alopecia and effects on quality of life among women with breast cancer: a literature review. Psycho-Oncology 2008;17:317-328.

Wills 2009

Wills S, Ravipati A, Nguyen M, Dana Z, Jaiyesimi I, Margolis J, Decker D. Scalp hypothermia minimizes alopecia in breast cancer patients receiving non-anthracycline adjuvant chemotherapy. Journal Cancer Research 2009;doi: 10.1158/0008-5472.SABCS-09-5040.

Lemieux 2009

Lemieux J, Amireault C, Provencher L, Maunsell E. Incidence of scalp metastases in breast cancer: a retrospective cohort study in women who were offered scalp cooling. Breast Cancer Research and Treatment 2009;118:547-552.